Description

Olpasiran is a first-in-class, siRNA designed to inhibit LPA mRNA translation in hepatocytes and thereby reduce plasma Lipoprotein(a) or Lp(a) concentration.

Product information

Targets: Lipoprotein(a); Lipoprotein

Synonym: Olpasiran

Chemical Name/IUPAC:

Chemical Name/IUPAC

Technical Data

Product Name	Olpasiran
Chemical Formula	(Duplex): C490H652F11N164O306P41S7
Molecular Weight	15438.70
CAS#	2225856-03-9
Appearance	Solid powder
Purity	> 99% by HPLC
Solubility	Soluble in DMSO
Storage	Room temperature for months, or -20ºC for 3 years

References

https://gsrs.ncats.nih.gov/ginas/app/beta/substances/8M4GC1EOB4

https://drugs.ncats.io/substance/8M4GC1EOB4

https://pubchem.ncbi.nlm.nih.gov/substance/472420032

Olpasiran-First In Class-Cholesterol Reducing