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13
Apr
Pushing the Limits of Detection: 2× Signal Amplification with Leadnano™ Streptavidin Beads
Enhancing assay sensitivity and expanding detection limits in chemiluminescence immunoassays.
For diagnostic assay developers, pushing detection limits while maintaining low background noise remains a critical challenge. Biofargo Leadnano™ Streptavidin magnetic beads are engineered to overcome this bottleneck by delivering superior signal amplification without compromising assay specificity.
Signal Amplification Validation
We conducted a Chemiluminescence Immunoassay (CLIA) evaluation targeting Thyroid Stimulating Hormone (TSH), comparing Biofargo 1 μm Streptavidin magnetic beads against leading Japanese competitor beads.
At baseline (0 antigen concentration), Biofargo beads maintained a clean background identical to controls, ensuring high assay specificity.
At low antigen concentrations, Biofargo beads delivered approximately 2× higher luminescence signals, significantly improving detection sensitivity.
At higher concentrations (125 μIU/mL), signal intensity remained ~2× higher, reaching up to 3.5M, confirming enhanced dynamic range.
Why It Matters
Upgrading capture materials can dramatically improve assay performance without redesigning your entire workflow.
- Enhanced sensitivity for ultra-low abundance biomarkers
- Expanded dynamic range for broader quantification
- Improved signal-to-noise ratio for clinical reliability
- Immediate performance upgrade for existing immunoassays
Biofargo Leadnano™ Streptavidin beads provide a validated, high-impact solution for next-generation diagnostic assay development.
Available Products
Biofargo team
